1.
Indian J Exp Biol
;
1977 Apr; 15(4): 290-3
Article
in English
| IMSEAR
| ID: sea-60483
Subject(s)
Animals , Female , Lipid Metabolism , Liver/enzymology , Malathion/analogs & derivatives , Male , Oxidoreductases/metabolism , Propoxur/poisoning , Rats
2.
Southeast Asian J Trop Med Public Health
;
1976 Sep; 7(3): 417-23
Article
in English
| IMSEAR
| ID: sea-34213
ABSTRACT
There is biochemical and clinical evidence that P-2-AM (Pyridine-2-Aldoxime Methiodide, Pralidoxime) does not reactive human acetylcholinesterase inhibited by either Malathion or Malaoxon. In vitro studies using Pralidoxime iodide up to ten times the recommended concentrations, produced insignificant reactivation of cholinesterases inhibited by Malathion or Malaoxon. This was observed inspite of prolonged exposure of the inhibited cholinesterases to the oxime. The value of Pralidoxime as a reactivator of phosphorylated cholinesterases is therefore in doubt, and should not be used in preference to large doses of atropine and other supportive treatment in poisoning by organophosphate pesticides.
Subject(s)
Acetylcholinesterase/blood , Butyrylcholinesterase/blood , Cholinesterase Inhibitors , Cholinesterases/blood , Enzyme Activation/drug effects , Humans , Malathion/analogs & derivatives , Pralidoxime Compounds/pharmacology
3.
Article
in English
| IMSEAR
| ID: sea-22416
Subject(s)
Animals , Depression, Chemical , Lipid Metabolism , Liver/enzymology , Malathion/analogs & derivatives , Male , Rats
4.
Indian J Biochem Biophys
;
1974 Sep; 11(3): 266-8
Article
in English
| IMSEAR
| ID: sea-27408